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Fig. 6 | Orphanet Journal of Rare Diseases

Fig. 6

From: Uncovering a novel SERPING1 pathogenic variant: insights into the aggregation of C1-INH in hereditary angioedema

Fig. 6

SERPING1 mutations induced cell apoptosis. (A) Flow cytometry was used to observe the apoptosis after single transfection of c.G550A, c.C566A, c.T708G and WT plasmid. (B) Statistical results of cell apoptosis by flow cytometry. (C) The BAL2 and BAX expression after co-transfecting with WT-HA + WT-GFP, c.G550A-HA + WT-GFP, c.C566A-HA + WT-GFP, and c.T708G-HA + WT-GFP. (D) Schematic diagram of apoptosis caused by c.708T> G mutation in hereditary angioedema. All experiments were independently performed at least three times to ensure repeatable results. Representative data in E and F are presented as mean ± SEM; *, P < 0.05; **, P < 0.001; ***, P < 0.001

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172