Associations between genetic variants of Toll-interacting proteins and interstitial lung diseases: a systematic review and meta-analysis

Table 2 Analysis of the association between the TOLLIP variants and susceptibility to ILD

Variants	Population	No. of studies	No. of alleles		Test of association			Test of heterogeneity
Variants	Population	No. of studies	Case	Control	OR	95%CI	p value	Model	p value	I²
rs5743890, C	Overall	8	4170	10,147	0.72	0.53-0.99	0.04	RE	<0.0000	80%
	IPF	6	3186	4440	0.62	0.44-0.86	0.004	RE	0.004	71%
rs111521887, G	Overall	6	3100	9022	1.48	1.33-1.65	<0.0000	FE	0.3	17%
rs3750920, T	Overall	5	5654	12,072	1.34	1.26-1.44	<0.0000	FE	0.23	29%

OR: odds ratio; CI: confidence interval; RE: R random effects model; FE: F fixed effects model

ISSN: 1750-1172