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Table 2 Comparison of the vascular density of the macular and peripapillary regions in different sectors (%)

From: Optical coherence tomography angiography reveals abnormal retinal vascular density and perfusion in patients with X-linked adrenoleukodystrophy: a cross-sectional study

Region

Layer

Sector

Healthy control group (n = 94)

Less symptomatic group (n = 62)

Symptomatic group (n = 40)

Wald Chi-square

p

p (pairwise comparisons)

L vs. C

S vs. C

S vs. L

Macular

Pericentral Ring SVC

S

54.281324 (53.074503–55.488146)

53.686327 (51.852345–55.520310)

51.266850 (48.055841–54.477860)

3.005

0.223

   

T

43.972240 (42.575828–45.368653)

43.242166 (41.672699–44.811634)

43.974670 (41.404428–46.544912)

0.517

0.772

   

I

54.470100 (52.998954–55.941246)

53.464719 (51.886200–55.043239)

52.836462 (50.093176–55.579748)

1.437

0.488

   

N

48.338259 (46.981180–49.695337)

47.313223 (45.359434–49.267011)

47.320205 (44.152005–50.488405)

0.872

0.646

   

Peripheral Ring SVC

S

51.364501 (49.986411–52.742591)

51.923123 (50.329983–53.516262)

47.105276 (44.144857–50.065695)

8.160

0.017

1.000

0.032

0.015

T

34.932885 (33.512706–36.353064)

35.366119 (34.169651–36.562588)

34.965155 (32.805288–37.125023)

0.243

0.886

   

I

50.697633 (49.389476–52.005790)

51.577269 (49.950075–53.204464)

48.396714 (45.486460–51.306968)

3.510

0.173

   

N

61.465818 (60.326055–62.605581)

60.702755 (58.797956–62.607554)

57.330694 (53.173092–61.488296)

3.713

0.156

   

Pericentral Ring DVC

S

59.758285 (59.068610–60.447961)

60.231405 (59.245774–61.217036)

60.259604 (59.214929–61.304280)

0.918

0.632

   

T

58.741731 (57.912611–59.570851)

59.156687 (58.109661–60.203713)

59.430314 (58.454315–60.406314)

1.148

0.563

   

I

59.315662 (58.609743–60.021580)

59.871681 (58.948242–60.795119)

59.666453 (58.567995–60.764910)

0.933

0.627

   

N

58.522529 (57.765851–59.279207)

58.743892 (57.466083–60.021701)

59.094852 (57.989529–60.200175)

0.705

0.703

   

Peripheral Ring DVC

S

58.452806 (57.656616–59.248996)

58.906794 (57.952080–59.861507)

57.963299 (56.959788–58.966810)

1.711

0.425

   

T

61.340332 (60.652744–62.027920)

61.527106 (60.612082–62.442131)

61.325855 (60.300071–62.351640)

0.121

0.941

   

I

56.879331 (56.038895–57.719767)

57.897844 (56.848547–58.947140)

56.673060 (55.406528–57.939593)

2.893

0.235

   

N

57.986857 (57.230822–58.742893)

58.317756 (57.205656–59.429857)

57.852909 (56.743164–58.962654)

0.366

0.833

   

Peripapillary

SVC

NS

63.888087 (61.787743–65.988431)

65.156755 (63.296139–67.017370)

61.818475 (58.125120–65.511830)

2.688

0.261

   

NI

55.635271 (53.336294–57.934248)

57.066187 (54.814684–59.317690)

56.040787 (51.765727–60.315847)

0.779

0.677

   

IN

74.978331 (72.984691–76.971970)

76.964952 (74.862155–79.067749)

70.965659 (66.383685–75.547632)

5.884

0.053

   

IT

84.990863 (83.782761–86.198964)

85.225973 (83.774866–86.677080)

82.787052 (79.660889–85.913214)

1.972

0.373

   

TI

68.262507 (66.329541–70.195474)

67.185890 (64.923926–69.447855)

66.527923 (62.348556–70.707291)

0.823

0.663

   

TS

68.236998 (66.486158–69.987838)

68.076213 (65.974280–70.178146)

64.565208 (59.976384–69.154032)

2.199

0.333

   

ST

82.017472 (80.606897–83.428048)

81.959173 (79.942691–83.975654)

78.953965 (75.552677–82.355252)

2.758

0.252

   

SN

77.802289 (75.899792–79.704787)

78.496889 (76.435514–80.558263)

72.861405 (69.500090–76.222720)

8.265

0.016

1.000

0.036

0.015

 Peripapillary

DVC

NS

35.681567 (33.466439–37.896695)

35.622752 (34.121345–37.124158)

37.543064 (34.837029–40.249098)

1.572

0.456

   

NI

43.661186 (41.413345–45.909028)

42.613352 (40.539001–44.687703)

43.234005 (40.109765–46.358244)

0.457

0.796

   

IN

22.433369 (19.810059–25.056679)

20.148194 (17.453405–22.842982)

27.357594 (22.874287–31.840902)

7.336

0.026

0.701

0.189

0.021

IT

15.659249 (13.672777–17.645721)

16.022908 (13.309437–18.736379)

19.403278 (15.511728–23.294827)

2.882

0.237

   

TI

47.288411 (45.443454–49.133367)

48.397776 (46.040669–50.754883)

48.335071 (45.129972–51.540170)

0.648

0.723

   

TS

46.717499 (44.826298–48.608700)

47.510584 (45.296577–49.724590)

49.118078 (46.798371–51.437785)

2.496

0.287

   

ST

20.194866 (17.808741–22.580990)

22.646105 (19.197710–26.094500)

22.241476 (19.083451–25.399500)

1.746

0.418

   

SN

18.672769 (16.143699–21.201840)

20.526671 (17.967245–23.086097)

23.290525 (19.826198–26.754852)

4.475

0.107

   
  1. 1. The data are expressed as the means (95% Wald confidence intervals). The bold values indicate statistical significance
  2. 2. C Healthy control group, L less symptomatic group, S symptomatic group