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Table 3 Comparison of the perfusion areas of the macular and peripapillary regions in different sectors (mm2)

From: Optical coherence tomography angiography reveals abnormal retinal vascular density and perfusion in patients with X-linked adrenoleukodystrophy: a cross-sectional study

Region

Layer

Sector

Healthy control group (n = 94)

Less symptomatic group (n = 62)

Symptomatic group (n = 40)

Wald Chi-Square

p

p (pairwise comparisons)

L vs. C

S vs. C

S vs. L

Macular

Pericentral Ring SVC

S

0.789122 (0.772622–0.805622)

0.781582 (0.755205–0.807960)

0.750569 (0.709795–0.791342)

2.969

0.227

   

T

0.657550 (0.641451–0.673649)

0.646582 (0.626651–0.666513)

0.652285 (0.620594–0.683976)

0.707

0.702

   

I

0.795362 (0.775112–0.815612)

0.779798 (0.757389–0.802208)

0.772074 (0.735882–0.808265)

1.685

0.431

   

N

0.709040 (0.691074–0.727007)

0.694261 (0.668796–0.719727)

0.693070 (0.653404–0.732736)

1.126

0.570

   

Peripheral Ring SVC

S

2.554641 (2.495977–2.613306)

2.577045 (2.502013–2.652077)

2.374338 (2.260190–2.488486)

9.242

0.010

1.000

0.018

0.011

T

1.903265 (1.850071–1.956459)

1.893645 (1.848007–1.939283)

1.877697 (1.791933–1.963461)

0.253

0.881

   

I

2.537223 (2.480297–2.594150)

2.555250 (2.478202–2.632298)

2.422042 (2.302383–2.541701)

3.594

0.166

   

N

2.969844 (2.909264–3.030423)

2.925360 (2.827699–3.023021)

2.763251 (2.577681–2.948822)

4.484

0.106

   

Pericentral Ring DVC

S

0.873891 (0.862336–0.885447)

0.880589 (0.864286–0.896891)

0.879834 (0.862579–0.897089)

0.567

0.753

   

T

0.848172 (0.835909–0.860436)

0.854395 (0.838088–0.870702)

0.857811 (0.842691–0.872931)

1.002

0.606

   

I

0.868136 (0.856493–0.879780)

0.875361 (0.860153–0.890570)

0.870517 (0.854125–0.886909)

0.548

0.761

   

N

0.849438 (0.837239–0.861638)

0.854973 (0.835011–0.874934)

0.857695 (0.838644–0.876746)

0.587

0.746

   

Peripheral Ring DVC

S

2.844040 (2.802705–2.885376)

2.880232 (2.834053–2.926411)

2.814037 (2.767951–2.860123)

3.965

0.138

   

T

2.940813 (2.898770–2.982856)

2.927429 (2.870790–2.984068)

2.924842 (2.861899–2.987786)

0.233

0.890

   

I

2.781810 (2.736399–2.827220)

2.829795 (2.770950–2.888640)

2.761747 (2.694046–2.829448)

2.544

0.280

   

N

2.860214 (2.819092–2.901336)

2.873161 (2.820494–2.925829)

2.817643 (2.748750–2.886536)

1.632

0.442

   

Peripapillary

SVC

NS

1.023538 (0.990281–1.056796)

1.045016 (1.017660–1.072372)

0.993672 (0.941253–1.046091)

3.141

0.208

   

NI

0.716957 (0.689551–0.744364)

0.734105 (0.706370–0.761840)

0.724592 (0.676904–0.772279)

0.744

0.689

   

IN

0.904493 (0.876398–0.932587)

0.932276 (0.904554–0.959998)

0.860083 (0.805829–0.914337)

5.838

0.054

   

IT

0.807224 (0.789919–0.824530)

0.812674 (0.796776–0.828572)

0.788414 (0.756249–0.820579)

1.760

0.415

   

TI

0.659257 (0.639740–0.678775)

0.646711 (0.624196–0.669227)

0.643548 (0.604764–0.682332)

0.918

0.632

   

TS

0.764949 (0.744517–0.785381)

0.766269 (0.742319–0.790220)

0.727912 (0.680823–0.775001)

2.217

0.330

   

ST

0.767085 (0.748347–0.785823)

0.770485 (0.749272–0.791699)

0.740013 (0.706779–0.773247)

2.466

0.291

   

SN

0.877937 (0.852615–0.903259)

0.888406 (0.862999–0.913814)

0.825055 (0.789598–0.860513)

8.556

0.014

1.000

0.051

0.013

DVC

NS

0.604935 (0.583616–0.626255)

0.610902 (0.597957–0.623846)

0.620660 (0.591691–0.649628)

0.739

0.691

   

NI

0.544581 (0.525964–0.563197)

0.534561 (0.517346–0.551777)

0.541958 (0.513215–0.570701)

0.629

0.730

   

IN

0.366365 (0.347975–0.384755)

0.348318 (0.329201–0.367435)

0.395638 (0.363552–0.427724)

6.360

0.042

0.547

0.361

0.039

IT

0.250599 (0.236864–0.264334)

0.258974 (0.240138–0.277810)

0.280861 (0.260702–0.301019)

5.930

0.052

   

TI

0.456193 (0.443801–0.468584)

0.465871 (0.449264–0.482478)

0.461177 (0.438615–0.483739)

0.852

0.653

   

TS

0.522169 (0.506989–0.537350)

0.533842 (0.515931–0.551753)

0.542555 (0.523079–0.562031)

2.755

0.252

   

ST

0.279935 (0.265124–0.294746)

0.297455 (0.276427–0.318483)

0.286655 (0.268565–0.304746)

1.789

0.409

   

SN

0.316083 (0.298208–0.333958)

0.334124 (0.315867–0.352382)

0.344346 (0.321210–0.367483)

3.993

0.136

   
  1. 1. The data are expressed as the means (95% Wald confidence intervals). The bold values indicate statistical significance
  2. 2. C Healthy control group, L less symptomatic group, S symptomatic group