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Table 4 Prevalence Rate of Clinical Events in the Overall Cohort and in the General Population

From: High clinical burden of classical homocystinuria in the United States: a retrospective analysis

 

Overall cohort with tHcy level (n = 601)

General population

Fractures, %

11.0

7.4a

Stroke/Transient ischemic attack, %

14.5

3.3b

Epilepsy, %

5.2

1.2c

Deep vein thrombosis or pulmonary embolism, %

17.3

0.3d

Ectopia lentis, %

2.2

0.006e

Osteoporosis, %

3.3

12.6f

  1. tHcy Total homocysteine
  2. aCalculated by major osteoporotic fracture probability in adults 50 and over [17]
  3. bPrevalence of stroke only, not including transient ischemic attack. From 2017 to 2020, ≥ 20 years of age [18]
  4. cPrevalence of active epilepsy [19]
  5. dCalculated based on 900,000 people with deep vein thrombosis or pulmonary embolism divided by the United States population, using 331,900,000 [20]
  6. eBased on a study in Denmark [21]
  7. fPrevalence of osteoporosis in adults 50 and over [22]
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172