Table 5 Health related quality of life (SF/RAND-36 and PROMIS-29) for total study population and skeletal dysplasia subgroups
|  | Total sample (N = 142) | ACH and HCH (n = 62) | OSD (n = 80) | Mean diff | CI 95% | p |
|---|---|---|---|---|---|---|
Mean (SD) | Mean (SD) | Mean (SD) | ||||
SF-36/RAND-36 | Â | Â | Â | Â | Â | Â |
 Physical functioning | 48.0 (29.6) | 56.7 (31.2) | 41.2 (26.6) | 15.5 | 5.7–25.4 | < 0.01 |
 Role limitations due to physical health | 42.4 (42.4) | 52.7 (43.6) | 34.3 (39.9) | 18.4 | 4.4–32.4 | 0.01 |
 Bodily pain | 50.3 (25.2) | 55.6 (25.6) | 46.1 (24.3) | 9.5 | 1.2–17.9 | < 0.05 |
 General health | 54.5 (23.7) | 62.3 (20.7) | 48.5 (24.1) | 13.8 | 6.2–21.4 | < 0.001 |
 Vitality | 47.2 (22.6) | 54.0 (21.8) | 41.8 (21.8) | 12.2 | 4.9–19.6 | 0.001 |
 Social functioning | 67.1 (26.6) | 72.2 (28.0) | 63.1 (24.9) | 9.0 | 0.2–17.9 | < 0.05 |
 Role limitations due to emotional health | 62.9 (42.5) | 71.0 (40.3) | 56.4 (43.4) | 14.6 | 0.4–28.7 | < 0.05 |
 Mental health | 69.7 (19.8) | 73.1 (18.5) | 67.0 (20.5) | 6.1 | − 0.5–12.7 | ns |
 PCS | 37.6 (11.2) | 41.4 (11.1) | 34.6 (10.4) | 6.8 | 3.2–10.4 | < 0.001 |
 MCS | 44.7 (9.9) | 47.6 (9.4) | 42.4 (9.8) | 5.2 | 1.9–8.5 | < 0.01 |
PROMIS-29 | Â | Â | Â | Â | Â | Â |
 Physical function | 39.5 (9.8) | 41.6 (10.0) | 37.9 (9.4) | 3.7 | 0.5–7.0 | < 0.05 |
 Ability to participate in social roles and activities | 48.3 (8.9) | 50.5 (8.5) | 46.7 (8.9) | 3.8 | 0.9–6.7 | 0.01 |
 Depression | 51.4 (9.7) | 50.5 (9.5) | 52.1 (9.9) | − 1.5 | − 4.8–1.7 | 0.36 |
 Anxiety | 52.4 (10.2) | 50.8 (10.5) | 53.5 (9.9) | − 2.7 | − 6.2–0.7 | 0.12 |
 Fatigue | 52.8 (10.4) | 49.7 (9.1) | 55.2 (10.8) | − 5.6 | − 8.9–− 2.3 | < 0.01 |
 Sleep disturbance | 50.7 (9.1) | 48.9 (8.1) | 52.1 (9.6) | − 3.1 | − 6.1–− 0.1 | < 0.05 |
 Pain interference | 58.4 (10.5) | 55.6 (10.4) | 60.6 (10.0) | − 5.0 | − 8.4–− 1.6 | < 0.01 |
 PCS | 39.9 (10.0) | 42.2 (10.1) | 38.0 (9.5) | 4.2 | 0.9–7.5 | 0.01 |
 MCS | 46.9 (8.9) | 49.5 (8.0) | 44.9 (9.1) | 4.6 | 1.7–7.5 | < 0.01 |