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Table 4 Clinical characteristics and outcomes across 3 PAP cluster groups

From: Phenotypic heterogeneity in mortality and prognosis of pulmonary alveolar proteinosis: a large-scale, global pooled analysis of individual-level data

Characteristic

Group

P value

G1 (N = 1689)

G2 (N = 546)

G3 (N = 1043)

G1 vs G2

G1 vs G3

G2 vs G3

Number of Death (%)

121 (7.16)

47 (8.61)

144 (13.81)

0.308

 < 0.001

0.003

Number of deaths attributed to the Respiratory System (%)

61 (50.41)

34 (72.34)

105 (72.92)

0.016

 < 0.001

 > 0.999

Number of deaths attributed to Respiratory failure (%)

38 (62.30)

22 (64.71)

83 (79.05)

0.091

 < 0.001

0.260

Number of deaths attributed to Lung Infections (%)

23 (47.70)

12 (35.29)

22 (20.95)

0.470

0.521

0.169

Sex Male (%)

823 (48.73)

326 (59.71)

726 (69.61)

0.524

0.029

0.018

PAP Type: Primary (%)

1523 (90.17)

445 (81.50)

935 (89.65)

 < 0.001

0.704

 < 0.001

Frequency of alveolar lavage

0.45 (0.45)

0.62 (0.46)

0.64 (0.45)

0.008

0.006

0.910

Frequency of repeated lung lavage

0.25 (0.38)

0.40 (0.47)

0.34 (0.45)

0.104

0.367

0.414

  1. 1. G1, asymptomatic group; G2, single symptom group; G3, two symptoms group
  2. 2. T-test or wilcoxon signed-rank test was used for continuous variables; Chi-square test was used for categorical variables