Fig. 5

Mental health. Respondents were asked to rate the mental health of the person with alpha-mannosidosis on a VAS scale now and 5 years ago, where 0 was ‘excellent mental health’ and 10 was ‘poor mental health’. (a) Mean (± SD) change in VAS scores 5 years ago to now stratified by treatment group (ERT, HSCT, UP), pediatric (< 16 years old) vs adults (≥ 16 years old) and length of time receiving ERT (< 5 years; ≥5 years). (b) Individual changes in VAS scores reported by patients showing scores 5 years ago and now for ERT, HSCT, and UP. Green shows improvement, grey no change, and purple worsening/decline; (c) Percentage of mental health issues reported by patients by treatment over the past 12 months: ERT (n = 23), HSCT (n = 7), and UP (n = 16). Respondents could select as many responses as applied. Hence, percentages are calculated as number of patients who chose this option over the number of total patients who responded to this question. ERT = enzyme replacement therapy; HSCT = hematopoietic stem cell transplantation; SD = standard deviation; UP = untreated patients; VAS = visual analogue scale