Table 8 A brief overview of the hepatotoxic signaling associated with onasemnogene abparvovec
alert signal | age | Sex | whether the event abated | concomitant medications | |||||
|---|---|---|---|---|---|---|---|---|---|
0−2year | 3-11year | 12−17year | ≥ 18year | Female | Male | Yes | No | ||
aspartate aminotransferase increased | 110 | 74 | 42 | 19 | 137 | 123 | 81 | 3 | prednisolone (148) famotidine (40) nusinersen (24) |
alanine aminotransferase increased | 104 | 61 | 26 | 33 | 127 | 109 | 72 | 3 | prednisolone (130) famotidine (36) nusinersen (18) |
hepatic enzyme increased | 81 | 34 | 8 | 16 | 118 | 103 | 22 | 1 | prednisolone (61) nusinersen (20) famotidine (19) |
liver function test increased | 30 | 27 | 4 | 14 | 51 | 43 | 10 | 0 | prednisolone (37) nusinersen (5) famotidine (3) |
transaminases increased | 36 | 17 | 10 | 9 | 42 | 38 | 18 | 0 | prednisolone (40) famotidine (16) nusinersen (12) |
hepatic function abnormal | 17 | 5 | 2 | 7 | 18 | 14 | 21 | 0 | prednisolone (21) famotidine (11) predonine (7) |
hypertransaminasaemia (31) | 12 | 8 | 3 | 4 | 13 | 13 | 6 | 0 | prednisolone (9) nusinersen (4) |
gamma-glutamyltransferase increased | 16 | 4 | 3 | 3 | 15 | 15 | 10 | 1 | prednisolone (13) famotidine (9) acetaminophen (5) |
blood bilirubin increased | 12 | 6 | 0 | 1 | 12 | 8 | 7 | 1 | prednisolone (10) famotidine (5) nusinersen (4) |