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Table 9 A comparative analysis of the hepatotoxic signalling ratio imbalance of onasemnogene abparvovec and its common concomitant drugs

From: Postmarketing adverse events associated with onasemnogene abeparvovec: a real-world pharmacovigilance study

alert signal

OA

prednisolone

famotidine

nusinersen

acetaminophen

aspartate aminotransferase increased

58.79

3.06

3.57

2.50

1.92

alanine aminotransferase increased

46.54

3.33

3.15

2.00

2.01

hepatic enzyme increased

40.78

1.74

1.25

1.57

3.43

liver function test increased

68.65

1.58

1.62

1.57

1.99

transaminases increased

43.48

2.78

1.22

2.80

1.8`1

hepatic function abnormal

10.35

4.70

3.90

0.74

0.83

hypertransaminasaemia (31)

66.64

2.48

1.07

3.16

1.56

gamma-glutamyltransferase increased

14.45

3.61

2.12

1.13

1.26

blood bilirubin increased

8.84

2.42

2.72

0.83

1.71