Table 2 Odevixibat treatment
Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | |
|---|---|---|---|---|---|
Starting daily dose | 120 µg/kg | 67 µg/kg | 37.2 µg/kg | 40 µg/kg | 37.5 µg/kg |
Dose escalation | No | No | 48 µg/kg | No | 65 µg/kg |
Dose at last follow-up | 110.3 µg/kg.d) (4800 µg/d) | 50 µg/kg.d (1200 µg/d) | 40 µg/kg.d (1200 µg/d) | 46 µg/kg.d (600 µg/d) | |
Duration of follow-up with treatment | 39 months | 39 months | 22 months | 22 months | 34 months |
Treatment interruption | Yes | No | No | Yes | No |
Treatment rechallenge | Yes | No | No | Yes, at 20 µg/kg.day then full dose 40 µg/kg.day | No |