Table 2 Comparison of serum markers and functional assessments during treatment versus baseline

Log10 CK (u/l)^a

2.34 ± 0.41

2.34 ± 0.37

2.30 ± 0.41

2.28 ± 0.34

2.33 ± 0.34

p = 0.879, p1 = 3.516

p = 0.330, p1 = 1.320

p = 0.053, p1 = 0.212

p = 0.733, p1 = 2.932

Cr (umol/l)^a

25.50 ± 11.94

27.89 ± 13.35

26.71 ± 11.11

26.46 ± 11.46

27.43 ± 11.37

p < 0.001

p = 0.784

p < 0.001

p = 0.072

CCR^a

28.63 ± 12.46

32.98 ± 13.15

33.20 ± 12.78

33.75 ± 14.47

35.22 ± 14.24

p < 0.001

p = 1.028

p < 0.001

p < 0.001

HFMSE^a

34.75 ± 24.78

35.79 ± 22.93

36.36 ± 22.23

36.68 ± 23.21

36.64 ± 23.39

p = 0.016

p = 0.012

p < 0.001

p < 0.001

RULM^b

31.50 (14.00–36.00)

33.50 (14.25-36.00)

33.5000 (19.50–36.00)

33.50 (19.25-37.00)

33.50 (19.25-37.00)

p = 0.024

p = 0.052

p = 0.032

p < 0.001

6WMT (m)^a

300.13 ± 151.15

295.07 ± 146.42

307.60 ± 152.78

300.13 ± 151.15

310.20 ± 153.45

p = 3.032

p = 3.044

p = 2.212

p = 0.332

BI^b

67.50 (36.25–83.75)

70.00 (36.25-85.00)

70.00 (36.25-90.00)

72.50 (36.25-90.00)

70.00 (40.00–95.00)

p = 0.800

p = 0.076

p = 0.008

p < 0.001