Serum creatinine to cystatin C ratio as monitoring biomarker in Chinese adult spinal muscular atrophy: a prospective cohort study

Table 3 Correlations between CK, Cr, CCR levels and basial functional assessment

variable	Log10(CK)	CCR	Cr
variable	(ρ, p-value)
Age (year)	-0.108, p = 0.584	-0.075, p = 0.704	-0.042, p = 0.833
Sex (male/female)	-0.335, p = 0.081	0.197, p = 0.316	0.045, p = 0.821
BMI (kg/m²)	-0.194, p = 0.332	-0.150, p = 0.446	-0.225, p = 0.250
SMN2 copy number (3/>3)	0.321, p = 0.096	0.507, p = 0.006	0.566, p = 0.002
Ambulant (yes/no)	0.478, p = 0.010	0.795, *p <* 0.001	0.760, p < 0.001
HFMSE	-0.532, p = 0.004	0.939, p < 0.001	0.897, p < 0.001
RULM	-0.598, *p <* 0.001	0.872, *p <* 0.001	0.806, p < 0.001
6WMT (m)	0.467, p = 0.059	0.823, p < 0.001	0.698, *p =* 0.002
BI	-0.525, p = 0.004	0.839, p < 0.001	0.765, p < 0.001
Log10 CK (u/l)	/	0.639, p < 0.001	0.665, *p <* 0.001
Cr (umol/l)	0.665, *p <* 0.001	0.962, p < 0.001	/
Cystatin (mg/l)	0.108, p = 0.586	-0.059, p = 0.766	0.162, *p =* 0.411
CCR	0.639, *p <* 0.001	/	0.962, *p <* 0.001

BMI: Body Mass Index; HFMSE: Hammersmith Functional Motor Scale Expanded; RULM, Revised Upper Limb Module; 6MWT: Six Minute Walk Test; BI: Barthel Index; CK: serum creatine kinase; Cr, serum creatinine; CCR: the creatinine to cystatin ratio

ISSN: 1750-1172