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Table 4 Correlation between biomarkers and functional scores in SMA over time

From: Serum creatinine to cystatin C ratio as monitoring biomarker in Chinese adult spinal muscular atrophy: a prospective cohort study

 

Variables

Adjusted model

p-value

  

β (95% CI)

 

CCR

HFMSE

0.280 (0.023–0.537)

0.033*

 

RULM

0.055 (-0.063-0.173)

0.356

 

BI

0.290 (-0.476-1.057)

0.455

Cr

HFMSE

-0.120 (-0.391-0.152)

0.635

 

RULM

0.031 (-0.097-0.159)

0.635

 

BI

0.088 (-0.718-0.894)

0.216

Log 10 CK

HFMSE

0.643 (-3.133-4.418)

0.736

 

RULM

-0.283 (-2.166-1.600)

0.766

 

BI

-1.425 (-12.324-9.474)

0.796

  1. HFMSE: Hammersmith Functional Motor Scale Expanded; RULM: Revised Upper Limb Module;
  2. 6MWT: Six Minute Walk Test; BI: Barthel Index; CK: serum creatine kinase; Cr, serum creatinine;
  3. CCR: the creatinine to cystatin ratio;
  4. *Significant based on the linear mixed-effects model with sex, time, SMN2 copy numbers and ambulant as covariates;
  5. Font bold: p < 0.05
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172