Orphanet Journal of Rare Diseases

Table 2 Ranking results of each treatment in the network

From: Efficacy of different treatment strategies in patients with mucopolysaccharidosis: a systematic review and network meta-analysis of randomized controlled trials

Type	Outcomes	Rank
Type	Outcomes	1	2	3	4	5	6	7
II	uGAG	idursulfase_1.5 mg/kg_Q2W	idursulfase_0.15 mg/kg_Q2W	idursulfase_0.5 mg/kg_Q2W	idursulfase_0.5 mg/kg_QW	idursulfase_1mg/kg_QW	idursulfase_IT_10mg	placebo
	CSF GAG	Idursulfase_IT_1mg	Idursulfase_IT_10mg	Idursulfase_IT_30mg	placebo
	6MWT	idursulfase_0.5 mg/kg_QW	idursulfase_1mg/kg_QW	idursulfase_0.5 mg/kg_Q2W	placebo
	FVC	idursulfase_1mg/kg_QW	idursulfase_0.5 mg/kg_QW	placebo	idursulfase_0.5 mg/kg_Q2W
	Liver V	idursulfase_0.5 mg/kg_QW	idursulfase_0.5 mg/kg_Q2W	idursulfase_1.5 mg/kg_Q2W	idursulfase_0.15 mg/kg_Q2W	placebo
III	uGAG	rhHNS_IT_10mg_Q4W	rhHNS_IT_90mg_Q4W	rhHNS_IT_45mg_Q4W	rhHNS_IT_45mg_Q2W	Genistein_160mg_QD	Genistein_10mg_QD	placebo
III	DQ	Genistein_160_mg_QD	rhHNS_IT_45_mg_Q4W	placebo	rhHNS_IT_45_mg_Q2W
IV	6MWT	elosulfase_alfa_4.0 mg/kg_QW	elosulfase_alfa_2.0 mg/kg_QW	elosulfase_alfa_2.0 mg/kg_Q2W	placebo
	3MSCT	idursulfase_1.5 mg/kg_Q2W	idursulfase_0.15 mg/kg_Q2W	idursulfase_0.5 mg/kg_Q2W	idursulfase_0.5 mg/kg_QW	idursulfase_1mg/kg_QW	idursulfase_IT_10mg	placebo
	uKS	Idursulfase_IT_1mg	Idursulfase_IT_10mg	Idursulfase_IT_30mg	placebo

3MSCT: 3-min stair climb test; 6MWT: 6-min walking test; CSF GAG: cerebrospinal fluid glycosaminoglycan; DQ: developmental quotient; FVC: forced vital capacity; uKS: urine keratan sulfate; uGAG: urinary glycosaminoglycan; Liver V: liver volumes

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ISSN: 1750-1172

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