Table 4 Analysis of comparison inconsistency and heterogeneity
| Â | Â | Â | Â | Inconsistency | Heterogeneity | Â | |
|---|---|---|---|---|---|---|---|
Type | Clinical outcome | Treat1 | Treat2 | Â | Â | Â | |
p.value | I2.pair(%) | I2.cons(%) | p.value | ||||
| Â | Â | idursulfase_0.5Â mg/kg_QW | idursulfase_0.5Â mg/kg_Q2W | 0.62 | NA | 0.00 | 0.82 |
| Â | Â | placebo | idursulfase_0.5Â mg/kg_Q2W | 0.63 | NA | 0.00 | 0.80 |
| Â | 6MWT | idursulfase_1mg/kg_QW | idursulfase_0.5Â mg/kg_QW | 0.66 | NA | 0.00 | 0.82 |
| Â | Â | placebo | idursulfase_0.5Â mg/kg_QW | 0.96 | 36.37 | 0.00 | 0.98 |
| Â | Â | placebo | idursulfase_1mg/kg_QW | 0.65 | NA | 0.00 | 0.82 |
| Â | Â | idursulfase_0.5Â mg/kg_Q2W | idursulfase_0.15Â mg/kg_Q2W | 0.48 | 37.26 | 96.30 | 0.68 |
II | Â | idursulfase_1.5Â mg/kg_Q2W | idursulfase_0.15Â mg/kg_Q2W | 0.98 | 87.17 | 76.86 | 0.99 |
| Â | Â | placebo | idursulfase_0.15Â mg/kg_Q2W | 0.37 | NA | 98.79 | 0.58 |
| Â | Â Liver V | idursulfase_0.5Â mg/kg_QW | idursulfase_0.5Â mg/kg_Q2W | 0.20 | NA | 90.01 | 0.47 |
| Â | Â | idursulfase_1.5Â mg/kg_Q2W | idursulfase_0.5Â mg/kg_Q2W | 0.50 | 0 | 96.24 | 0.69 |
| Â | Â | placebo | idursulfase_0.5Â mg/kg_Q2W | 0.57 | 99.59 | 98.81 | 0.72 |
| Â | Â | placebo | idursulfase_0.5Â mg/kg_QW | 0.20 | NA | 90.61 | 0.47 |
| Â | Â | placebo | idursulfase_1.5Â mg/kg_Q2W | 0.43 | NA | 98.70 | 0.62 |
| Â | Â | Idursulfase_IT_1mg | Idursulfase_IT_10mg | 0.99 | NA | 0.00 | 0.99 |
| Â | Â | Idursulfase_IT_30mg | Idursulfase_IT_10mg | 0.54 | 38.58 | 0.00 | 0.82 |
| Â | Â CSF GAG | placebo | Idursulfase_IT_10mg | 0.50 | 0 | 0.00 | 0.87 |
| Â | Â | Idursulfase_IT_30mg | Idursulfase_IT_1mg | 0.79 | NA | 0.00 | 0.86 |
| Â | Â | placebo | Idursulfase_IT_1mg | 0.75 | NA | 0.00 | 0.79 |
| Â | Â | placebo | Idursulfase_IT_30mg | 0.60 | NA | 0.00 | 0.66 |
| Â | Â | idursulfase_0.5Â mg/kg_QW | idursulfase_0.5Â mg/kg_Q2W | 0.85 | NA | 0.00 | 0.96 |
| Â | Â | placebo | idursulfase_0.5Â mg/kg_Q2W | 0.86 | NA | 0.00 | 0.95 |
| Â | FVC | idursulfase_1mg/kg_QW | idursulfase_0.5Â mg/kg_QW | 0.78 | NA | 0.00 | 0.82 |
| Â | Â | placebo | idursulfase_0.5Â mg/kg_QW | 1.00 | 0 | 0.00 | 0.97 |
| Â | Â | placebo | idursulfase_1mg/kg_QW | 0.78 | NA | 0.00 | 0.88 |
| Â | Â | idursulfase_0.5Â mg/kg_Q2W | idursulfase_0.15Â mg/kg_Q2W | 0.92 | NA | 0.00 | 0.96 |
| Â | uGAG | idursulfase_1.5Â mg/kg_Q2W | idursulfase_0.15Â mg/kg_Q2W | 0.99 | NA | 0.00 | 1.00 |
| Â | Â | placebo | idursulfase_0.15Â mg/kg_Q2W | 0.93 | NA | 0.00 | 0.95 |
| Â | Â | idursulfase_0.5Â mg/kg_QW | idursulfase_0.5Â mg/kg_Q2W | 0.32 | NA | 45.55 | 0.77 |
| Â | Â | idursulfase_1.5Â mg/kg_Q2W | idursulfase_0.5Â mg/kg_Q2W | 0.91 | NA | 0.00 | 0.96 |
| Â | Â | placebo | idursulfase_0.5Â mg/kg_Q2W | 0.43 | 0 | 0.00 | 0.78 |
II | uGAG | idursulfase_1mg/kg_QW | idursulfase_0.5Â mg/kg_QW | 0.43 | NA | 55.29 | 0.84 |
| Â | Â | placebo | idursulfase_0.5Â mg/kg_QW | 0.93 | 89.75 | 79.13 | 0.99 |
| Â | Â | placebo | idursulfase_1.5Â mg/kg_Q2W | 0.91 | NA | 0.00 | 0.95 |
| Â | Â | placebo | idursulfase_1mg/kg_QW | 0.43 | NA | 49.15 | 0.83 |
| Â | Â | rhHNS_IT_45mg_Q2W | placebo | 1.00 | NA | 0.00 | 1.00 |
| Â | Â | rhHNS_IT_45mg_Q4W | placebo | 1.00 | NA | 0.00 | 0.99 |
 III |  uGAG | rhHNS_IT_45mg_Q4W | rhHNS_IT_10mg_Q4W | 1.00 | NA | 0.00 | 1.00 |
| Â | Â | rhHNS_IT_90mg_Q4W | rhHNS_IT_10mg_Q4W | 1.00 | NA | 0.00 | 1.00 |
| Â | Â | rhHNS_IT_45mg_Q4W | rhHNS_IT_45mg_Q2W | 0.99 | NA | 0.00 | 0.99 |
| Â | Â | rhHNS_IT_90mg_Q4W | rhHNS_IT_45mg_Q4W | 1.00 | NA | 0.00 | 1.00 |
III | DQ | rhHNS_IT_45_mg_Q2W | placebo | 0.88 | 0 | 0.00 | 0.92 |
| Â | Â | rhHNS_IT_45_mg_Q4W | placebo | 0.91 | 0 | 0.00 | 0.92 |
| Â | Â | rhHNS_IT_45_mg_Q4W | rhHNS_IT_45_mg_Q2W | 0.90 | 8.46 | 0.00 | 0.89 |
| Â | Â | elosulfase_alfa_2.0Â mg/kg_QW | elosulfase_alfa_2.0Â mg/kg_Q2W | 0.78 | NA | 0.00 | 0.97 |
| Â | 3MSCT | placebo | elosulfase_alfa_2.0Â mg/kg_Q2W | 0.78 | NA | 0.00 | 0.97 |
| Â | Â | placebo | elosulfase_alfa_2.0Â mg/kg_QW | 0.77 | 76.11 | 27.73 | 0.86 |
| Â | Â | elosulfase_alfa_2.0Â mg/kg_QW | elosulfase_alfa_2.0Â mg/kg_Q2W | 0.49 | NA | 99.98 | 0.58 |
IV | uKS | placebo | elosulfase_alfa_2.0Â mg/kg_Q2W | 0.50 | NA | 99.98 | 0.58 |
| Â | Â | placebo | elosulfase_alfa_2.0Â mg/kg_QW | 0.50 | 100 | 99.99 | 0.60 |
| Â | Â | elosulfase_alfa_2.0Â mg/kg_QW | elosulfase_alfa_2.0Â mg/kg_Q2W | 0.84 | NA | 0.00 | 0.90 |
| Â | 6MWT | placebo | elosulfase_alfa_2.0Â mg/kg_Q2W | 0.84 | NA | 0.00 | 0.89 |
| Â | Â | placebo | elosulfase_alfa_2.0Â mg/kg_QW | 0.84 | 0 | 0.00 | 0.87 |