Table 4 Health state utilities based on HUI-3, EQ-5D-5L and TTO valuations of health state vignettes
From: Leber hereditary optic neuropathy: utilities and carer burden from British and Irish participants
HUI-3 utilities mean (95% CI) | EQ-5D-5L utilities mean (95% CI) | TTO utilities mean (95% CI) | |||||||
|---|---|---|---|---|---|---|---|---|---|
Health state (LogMAR) | Total sample (N = 362) | UK sample (N = 301) | ROI sample (N = 61) | Total sample (N = 358) | UK sample (N = 297) | ROI sample (N = 61) | Total sample (N = 120) | UK sample (N = 100) | ROI sample (N = 20) |
(< 0.3) | 0.837 (0.808–0.866) | 0.838 (0.807–0.870) | 0.829 (0.755–0.902) | 0.790 (0.770–0.810) | 0.786 (0.763–0.809) | 0.810 (0.776–0.844) | 0.882 (0.859–0.905) | 0.874 (0.847–0.901) | 0.921 (0.888–0.954) |
(≥ 0.3 and < 0.6) | 0.511 (0.478–0.543) | 0.504 (0.468–0.539) | 0.548 (0.467–0.63) | 0.632 (0.609–0.654) | 0.625 (0.600–0.651) | 0.663 (0.627–0.699) | 0.756 (0.708–0.804) | 0.746 (0.69–0.802) | 0.806 (0.736–0.877) |
(≥ 0.6 and < 1.0) | 0.435 (0.404–0.466) | 0.436 (0.404–0.469) | 0.427 (0.339–0.514) | 0.574 (0.549–0.600) | 0.583 (0.555–0.611) | 0.534 (0.471–0.596) | 0.702 (0.65–0.754) | 0.686 (0.625–0.746) | 0.785 (0.709–0.861) |
(≥ 1.0 and < 1.3) | 0.347 (0.315–0.378) | 0.351 (0.317–0.385) | 0.324 (0.237–0.41) | 0.495 (0.468–0.523) | 0.506 (0.478–0.535) | 0.439 (0.358–0.521) | 0.565 (0.495–0.635) | 0.546 (0.466–0.627) | 0.658 (0.539–0.776) |
(≥ 1.3 and < 1.7) | 0.325 (0.295–0.354) | 0.314 (0.281–0.346) | 0.376 (0.305–0.447) | 0.497 (0.469–0.525) | 0.498 (0.468–0.528) | 0.490 (0.414–0.566) | 0.525 (0.448–0.602) | 0.496 (0.408–0.584) | 0.668 (0.539–0.796) |
(~ 2.0) | 0.211 (0.188–0.234) | 0.212 (0.187–0.238) | 0.204 (0.156–0.252) | 0.368 (0.342–0.394) | 0.373 (0.344–0.402) | 0.343 (0.281–0.405) | 0.406 (0.319–0.494) | 0.391 (0.29–0.492) | 0.485 (0.337–0.633) |
(~ 2.3) | 0.190 (0.164–0.216) | 0.183 (0.153–0.212) | 0.223 (0.163–0.283) | 0.347 (0.315–0.378) | 0.343 (0.307–0.378) | 0.365 (0.295–0.434) | 0.426 (0.348–0.504) | 0.404 (0.316–0.493) | 0.535 (0.397–0.673) |
(~ 4.0) | 0.180 (0.154–0.206) | 0.177 (0.149–0.205) | 0.193 (0.127–0.259) | 0.341 (0.312–0.370) | 0.339 (0.306–0.371) | 0.354 (0.292–0.415) | 0.363 (0.279–0.447) | 0.342 (0.246–0.438) | 0.469 (0.326–0.611) |