Skip to main content

Table 2 Genotype distribution and allele frequencies of SLC6A4 gene polymorphisms among study groups

From: Genetic variants of SLC6A4 and risk of coronary artery disease: insights from North Indian population

POLYMORPHISM/

GENOTYPE/ ALLELE

CAD PATIENTS

(n = 400) (%)

CONTROLS

(n = 400) (%)

OR (95% CI)

Adjusted p-value

5-HTTLPR

SS

SL

LL

S

L

χ2

210 (52.5%)

150 (37.5%)

40 (10%)

0.7

0.3

2.86 (p = 0.1)

245 (61.25%)

130 (32.5%)

25 (6.25%)

0.77

0.23

1.85 (p = 0.2)

1 (Ref.)

1.35 (1.0-1.81)

1.87 (1.10–3.18)

1 (Ref.)

1.39 (1.11–1.74)

0.05

0.03*

0.01*

rs25531

S’ S’

S’LA

LALA

S’

LA

χ2

276 (69%)

107 (26.75%)

17 (4.25%)

0.82

0.18

2.48 (p = 0.11)

288 (72%)

97 (24.25%)

15 (3.75%)

0.84

0.16

3.39(p = 0.06)

1 (Ref.)

1.15 (0.83–1.59)

1.18 (0.58–2.41)

1(Ref.)

1.13 (0.87–1.47)

0.6

0.64

0.9

VNTR STin2

12/12 rpts

12/10 rpts

10/10 rpts

12 rpt

10 rpt

χ2

190 (47.5%)

171 (42.75%)

39 (9.75%)

0.69

0.31

0.50 (p = 0.47)

180 (45%)

167 (41.75%)

53 (13.25%)

0.66

0.34

2.04 (p = 0.15)

1 (Ref.)

0.97 (0.72–1.03)

0.70 (0.44–1.11)

1 (Ref.)

0.87 (0.71–1.07)

0.8

0.3

0.3

  1. *Significant p-values